- Original Article
- Cardiology
- Changes of Bax, Bcl-2, CCR-2, MCP-1, and TGF-β1 genes in the left ventricle of spontaneously hypertensive rat after losartan treatment
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Hyeryon Lee, Kwan Chang Kim, Young Mi Hong
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Clin Exp Pediatr. 2019;62(3):95-101. Published online October 24, 2018
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Purpose: Increased apoptosis was recently found in the hypertrophied left ventricle of spontaneously hypertensive rats (SHRs). Although the available evidence suggests that apoptosis can be induced in cardiac cells by various insults including pressure overload, cardiac apoptosis appears to result from an exaggerated local production of angiotensin in adult SHRs. Altered expressions of Bcl associated X (Bax), Bcl-2, chemokine receptor... |
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- Change of voltage-gated potassium channel 1.7 expressions in monocrotaline-induced pulmonary arterial hypertension rat model
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Hyeryon Lee, Kwan Chang Kim, Young Mi Hong
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Clin Exp Pediatr. 2018;61(9):271-278. Published online September 15, 2018
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Purpose: Abnormal potassium channels expression affects vessel function, including vascular tone and proliferation rate. Diverse potassium channels, including voltage-gated potassium (Kv) channels, are involved in pathological changes of pulmonary arterial hypertension (PAH). Since the role of the Kv1.7 channel in PAH has not been previously studied, we investigated whether Kv1.7 channel expression changes in the lung tissue of a monocrotaline... |
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- Apoptosis and remodeling in adriamycin-induced cardiomyopathy rat model
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Young Mi Hong, Hyeryon Lee, Min-Sun Cho, Kwan Chang Kim
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Clin Exp Pediatr. 2017;60(11):365-372. Published online November 27, 2017
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Purpose The mechanism for the pathogenesis of adriamycin (ADR)-induced cardiomyopathy is not yet known. Different hypotheses include the production of free radicals, an interaction between ADR and nuclear components, and a disruption in cardiac-specific gene expression. Apoptosis has also been proposed as being involved in cardiac dysfunction. The purpose of this study was to determine if apoptosis might play a role... |
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- The effect of sildenafil on right ventricular remodeling in a rat model of monocrotaline-induced right ventricular failure
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Hyun Kyung Bae, Hyeryon Lee, Kwan Chang Kim, Young Mi Hong
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Clin Exp Pediatr. 2016;59(6):262-270. Published online June 30, 2016
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Purpose Pulmonary arterial hypertension (PAH) leads to right ventricular failure (RVF) as well as an increase in pulmonary vascular resistance. Our purpose was to study the effect of sildenafil on right ventricular remodeling in a rat model of monocrotaline (MCT)-induced RVF. MethodsThe rats were distributed randomly into 3 groups. The control (C) group, the monocrotaline (M) group (MCT 60 mg/kg) and the... |
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- Uveitis as an important ocular sign to help early diagnosis in Kawasaki disease
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Han Seul Choi, Seul Bee Lee, Jung Hyun Kwon, Hae Soon Kim, Sejung Sohn, Young Mi Hong
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Clin Exp Pediatr. 2015;58(10):374-379. Published online October 21, 2015
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Purpose Incomplete Kawasaki disease (KD) is frequently associated with delayed diagnosis and treatment. Delayed diagnosis leads to increasing risk of coronary artery aneurysm. Anterior uveitis is an important ocular sign of KD. The purpose of this study was to assess differences in laboratory findings, including echocardiographic measurements, clinical characteristics such as fever duration and treatment responses between KD patients with and... |
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- Associations of matrix metalloproteinase (MMP)-8, MMP-9, and their inhibitor, tissue inhibitor of metalloproteinase-1, with obesity-related biomarkers in apparently healthy adolescent boys
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Youn Ho Shin, Ki Eun Kim, Yong-Jae Lee, Jae-Hwan Nam, Young Mi Hong, Hye-Jung Shin
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Clin Exp Pediatr. 2014;57(12):526-532. Published online December 31, 2014
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Purpose Matrix metalloproteinases (MMPs) have been implicated in atherosclerosis, and therefore, are considered risk factors for metabolic dysfunction in adults. However, there is little data on circulating levels of MMPs and tissue inhibitors of MMPs (TIMPs) with regard to obesity-related biomarkers in the general adolescent population. In the present study, we determined the associations of MMP-8, MMP-9, and TIMP-1 levels and... |
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- An inhibitory effect of tumor necrosis factor-alpha antagonist to gene expression in monocrotaline-induced pulmonary hypertensive rats model
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Jung Hyun Kwon, Kwan Chang Kim, Min-Sun Cho, Hae Soon Kim, Sejung Sohn, Young Mi Hong
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Clin Exp Pediatr. 2013;56(3):116-124. Published online March 18, 2013
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Purpose Tumor necrosis factor (TNF)-α is thought to contribute to pulmonary hypertension. We aimed to investigate the effect of infliximab (TNF-α antagonist) treatment on pathologic findings and gene expression in a monocrotaline-induced pulmonary hypertension rat model. MethodsSix-week-old male Sprague-Dawley rats were allocated to 3 groups: control (C), single subcutaneous injection of normal saline (0.1 mL/kg); monocrotaline (M), single subcutaneous injection of monocrotaline... |
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- Review Article
- Cardiomyopathies in children
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Young Mi Hong
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Clin Exp Pediatr. 2013;56(2):52-59. Published online February 25, 2013
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Cardiomyopathy (CMP) is a heterogeneous disease caused by a functional abnormality of the cardiac muscle. CMP is of 2 major types, dilated and hypertrophic, and is further classified as either primary or secondary. Secondary CMP is caused by extrinsic factors, including infection, ischemia, hypertension, and metabolic disorders. Primary CMP is diagnosed when the extrinsic factors of secondary CMP are absent.... |
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- Original Article
- The relationships of body mass index, waist-to-height ratio, and body fat percentage with blood pressure and its hemodynamic determinants in Korean adolescents: a school-based study
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Na Young Kim, Young Mi Hong, Jo Won Jung, Nam Su Kim, Chung Il Noh, Young-Hwan Song
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Clin Exp Pediatr. 2013;56(12):526-533. Published online December 20, 2013
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Purpose Obesity is an important risk factor for hypertension in adolescents. We investigated the relationship of obesity-related indices (body mass index [BMI], waist-to-height ratio [WHR], and body fat percentage [%BF]) with blood pressure and the hemodynamic determinants of blood pressure in Korean adolescents. MethodsIn 2008, 565 adolescents, aged 12-16 years, were examined. The %BF of the participants was measured by bioelectrical impedance... |
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- Epidemiology of Kawasaki disease in infants 3 months of age and younger
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Eun Jung Lee, Yong Won Park, Young Mi Hong, Joon Sung Lee, Ji Whan Han
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Clin Exp Pediatr. 2012;55(6):202-205. Published online June 21, 2012
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Purpose This study investigated the epidemiology of Kawasaki disease (KD) in infants ≤3-month-old. MethodsTo study the epidemiology of KD in Korea, data for 27,851 KD patients were collected on a 3-year basis between 2000 and 2008 in a retrospective survey. From this, data for 609 KD patients ≤3-month-old were analyzed and compared with the data for KD patients >3-month-old. ResultsThe 609 KD patients... |
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- Clinical characteristics of obese boys and girls in a high school: focused on abdominal fat indices, fatty liver and carotid intima-media thickness
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Jung Eun Oh, Jiyoung Jung, Hae Soon Kim, Young Mi Hong, Jung Hyun Yoo, Young Whan Song, Jo Won Jung, Nam Su Kim, Chung Il Noh
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Clin Exp Pediatr. 2011;54(7):292-297. Published online July 31, 2011
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Purpose Our study aimed to evaluated sex differences in clinical features of obese high school students. MethodsOne hundred three obese high school students (body mass index [BMI]≥85th percentile) and 51 control students (BMI<85th percentile) were enrolled in this study. Anthropometric measurements were performed. Fasting serum glucose, insulin, aspartate aminotransferase, alanine aminotransferase, total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C),... |
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- Mycoplasma pneumoniae infection in patients with Kawasaki disease
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Mi Na Lee, Jie Hae Cha, Hye Mi Ahn, Jeong Hyun Yoo, Hae Soon Kim, Sejung Sohn, Young Mi Hong
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Clin Exp Pediatr. 2011;54(3):123-127. Published online March 31, 2011
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Purpose Kawasaki disease (KD) is the main cause of acquired heart disease in children. In addition to cardiovascular involvement, many complications have been recognized in KD. However, respiratory complications have been rarely reported. We investigated the differences in clinical characteristics, laboratory findings, radiography findings, and echocardiography findings of Mycoplasma pneumoniae infection and other types of pneumonia in KD patients. MethodsAmong 358 patients... |
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- Enterovirus 71-associated hand, foot and mouth diseases with neurologic symptoms, a university hospital experience in Korea, 2009
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Hye Kyung Cho, Na Yong Lee, Hyunju Lee, Hae Soon Kim, Jeong Wan Seo, Young Mi Hong, Seung Joo Lee, Sun Wha Lee, Doo Sung Cheon, Ji Young Hong, Byung Hak Kang, Jong-Hyun Kim, Kyung-Hyo Kim
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Clin Exp Pediatr. 2010;53(5):639-643. Published online May 31, 2010
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Purpose Hand-foot-mouth disease (HFMD) is a common viral illness in children, which is usually mild and self-limiting. However, in recent epidemics of HFMD in Asia, enterovirus 71 (EV71) has been recognized as a causative agent with severe neurological symptoms with or without cardiopulmonary involvement. HFMD was epidemic in Korea in the spring of 2009. Severe cases with complications including death have... |
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- Body composition by bioelectrical impedance analysis in children below 7 years old
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Jiyoung Jung, Han Wool Kim, Tae Hyun Kim, Young Mi Hong
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Clin Exp Pediatr. 2010;53(3):341-348. Published online March 15, 2010
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Purpose : Body composition is important to define and manage obesity and undernutrition. Obesity is a significant health problem with medical and psychological consequences for children and adolescents. Body composition analysis (BIA) is a simple, rapid, noninvasive, and reproducible technique. However, comparative analysis of body composition has not been done in young children below 7 years old. The aim of... |
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- Serum interleukin-6, tumor necrosis factor-α and adiponectin levels in Kawasaki disease
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Jung Ahn, Han Gyu Kim, Sejung Sohn, Young Mi Hong
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Clin Exp Pediatr. 2010;53(1):41-47. Published online January 15, 2010
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Purpose : Adiponectin is an endogenous modulator of vascular remodeling that suppresses vascular inflammation. However, the role of adiponectin in Kawasaki disease (KD) has not been elucidated. The purpose of this study is to investigate the correlation between serum adiponectin level and several parameters, such as interleukin (IL)-6, tumor necrosis factor (TNF)-α, lipid profile, and C reactive protein (CRP), and... |
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- Left ventricular dysfunction measured by tissue Doppler imaging and strain rate imaging in hypertensive adolescents
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Hye Mi Ahn, Sun Ok Jung, Jung Hyun Kwon, Young Mi Hong
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Clin Exp Pediatr. 2010;53(1):72-79. Published online January 15, 2010
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Purpose : Left ventricular (LV) hypertrophy and impaired diastolic function may occur early in systemic hypertension. Diastolic dysfunction is associated with increased cardiovascular risk. Tissue Doppler imaging (TDI)-derived tissue velocity and strain rate are new parameters for assessing diastolic dysfunction. The aim of this study is to determine whether TDI and strain rate imaging (SRI) would improve the ability to... |
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- Review Article
- Metabolic syndrome in children and adolescents
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Young Mi Hong
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Clin Exp Pediatr. 2009;52(7):737-744. Published online July 15, 2009
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Metabolic syndrome (MS) in children and adolescents has become a global public health problem. MS among Korean children and adolescents has been increasing significantly over the past decade.
This paper aims to provide the currently available information on the MS in children and adolescents. This review focuses on the definition, diagnostic criteria, epidemiology and pathophysiology which may be helpful for... |
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- Original Article
- Effect of endothelin receptor blockade on monocrotaline-induced pulmonary hypertension in rats
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Kyoung Ah Lim, Jung Yun Shim, Sang Ho Cho, Kwan Chang Kim, Jae Jin Han, Young Mi Hong
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Clin Exp Pediatr. 2009;52(6):689-695. Published online June 15, 2009
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Purpose : To examine the effect of bosentan, a dual endothelin receptor (ER) antagonist, on the development of monocrotaline (MCT)-induced pulmonary hypertension in rats by especially focusing on the pulmonary vascular morphology changes.
Methods : Sprague-Dawley rats were treated as follows: controls received a subcutaneous saline injection, MCT-treated rats received a subcutaneous MCT injection, and bosentan-treated rats received a MCT... |
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- Serum level of the adiponectin and adiponectin I164T polymorphism in hypertensive adolescents
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Jung Ah Lee, Joo Hyun Gil, Young Mi Hong
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Clin Exp Pediatr. 2009;52(2):187-193. Published online February 15, 2009
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Purpose : Adiponectin is a molecule that plays an important role in the metabolic syndrome. In addition, its concentration is known to be decreased in obesity, type 2 diabetes, and coronary artery disease. Although a relationship between hypertension and serum adiponectin concentrations has been reported by several authors, such findings continue to be debated. We investigated whether hypoadiponectinemia is related... |
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- Angiotensinogen gene M235T polymorphism as a predictor of cardiovascular risk in hypertensive adolescents
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Joo Hyun Gil, Jung Ah Lee, Eun Young Park, Young Mi Hong
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Clin Exp Pediatr. 2009;52(1):36-43. Published online January 15, 2009
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Purpose : The renin-angiotensin system (RAS) has been demonstrated to play a major role in regulating blood pressure. Therefore, components of the RAS are likely candidate genes that may predispose an individual to essential hypertension and cardiovascular complications. Among them, the M235T polymorphism of the angiotensinogen gene has been speculated to be associated with elevated circulating angiotensinogen concentrations and essential... |
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- Normal blood pressure values and percentile curves measured by oscillometric method in children under 6 years of age
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Jin A Sohn, Hee Sook Lee, Kyoung Aha Lim, So Young Yoon, Jo Won Jung, Nam Su Kim, Chung Il Noh, Soon Young Lee, Young Mi Hong
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Clin Exp Pediatr. 2008;51(9):998-1006. Published online September 15, 2008
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Purpose : Hypertension is defined as average systolic blood pressure and/or diastolic blood pressure that is ≥95th percentile for gender, age, and height on ≥three occasions. Knowing that blood pressure values increase in children as they grow older, the purposes of this study were to measure blood pressure by an oscillometric device and to determine normal values and percentile curves... |
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- Leptin, adiponectin, interleukin-6 and
tumor necrosis factor- in obese adolescents
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Joo Hyun Gil, Jung Ah Lee, Ji Young Kim, Young Mi Hong
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Clin Exp Pediatr. 2008;51(6):597-603. Published online June 15, 2008
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Purpose : Obesity is associated with insulin resistance. Insulin resistance and the presence of pro-inflammatory mediators are thought to cause a state of vascular endothelial dysfunction, an abnormal lipid profile, hypertension, and vascular inflammation. These chronic inflammatory responses, which are characterized by abnormal cytokine production, lead to activation of a pro-inflammatory signaling pathway. Leptin is an important mediator of inflammatory... |
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- Pulse wave velocity and ankle brachial index in normal adolescents
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Ji Hye Kim, Tae Young Gil, Hee Woo Lee, Young Mi Hong
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Clin Exp Pediatr. 2007;50(6):549-555. Published online June 15, 2007
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Purpose : Pulse wave velocity (PWV) and ankle brachial index (ABI) are simple, non-invasive methods to assess arterial stiffness. These parameters are also known to be closely related to cardiovascular risk factors and diseases. The purposes of this study were to measure blood pressure, PWV, ABI in healthy Korean adolescents, set up their normal values and assess their correlations.
Methods... |
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- Pulse wave velocity and ankle brachial index in obese adolescents
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Ji Hye Kim, Hee Sun Koo, Young Mi Hong
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Clin Exp Pediatr. 2007;50(11):1078-1084. Published online November 15, 2007
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Purpose : The prevalence of childhood obesity has doubled over the last 30 years. Obesity-associated sequelae in the vasculature begins in the early stages of life. The purpose of this study was to investigate how pulse wave velocity (PWV) and ankle brachial index (ABI) change with height, weight and body mass index (BMI) in obese adolescents.
Methods : Seventy-nine obese... |
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- Pulse wave velocity and ankle brachial index in adolescents with essential hypertension
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Sun Young Joo, Ki Young Cho, Su Jin Cho, Young Mi Hong
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Clin Exp Pediatr. 2006;49(7):769-776. Published online July 15, 2006
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Purpose : Pulse wave velocity(PWV) and ankle brachial index(ABI) are not only noninvasive methods used to assess arterial stiffness in adults, but also useful, simple ways to estimate the severity of hypertension, end stage renal disease and atherosclerosis in adults. But there are few studies on PWV and ABI in adolescents and children. In this study, hypertensive adolescents were compared... |
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- Homocysteine, insulin, vitamin B12 and folic acid levels in obese children
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Jee Yoon Park, Young Mi Hong
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Clin Exp Pediatr. 2006;49(5):475-481. Published online May 15, 2006
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Purpose : As the prevalence of childhood obesity is increasing, hypertension, hyperlipidemia, insulin resistance and diabetes mellitus have become problems. High homocysteine levels and low vitamin B12 supplementation are acknowledged to have a role in coronary artery disease, but there are few studies on homocysteine, insulin and vitamin B12 levels in obese children. We aimed to study whether homocysteine, insulin,... |
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- Modified Tei index in patients with Kawasaki disease by tissue doppler imaging
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Hee Jung Kim, Jung Hwa Cha, Young Mi Hong
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Clin Exp Pediatr. 2006;49(11):1202-1210. Published online November 15, 2006
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Purpose : A quantitative and easily measured Doppler index of combined systolic and diastolic ventricular myocardial performance (Tei index) was recently proposed as a potentially useful predictor of global myocardial performance. However, presence of heart rate fluctuation makes it unreliable. Therefore, the modified Tei index was introduced by using tissue Doppler imaging (TDI) which enables measuring contraction and relaxation velocities... |
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- Serum homocysteine and tumor necrosis factor-alpha levels after intravenous gammaglobulin treatment in patients with Kawasaki disease
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Jung Hwa Cha, Young Mi Hong
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Clin Exp Pediatr. 2006;49(10):1093-1099. Published online October 15, 2006
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Purpose : Homocysteine is a strong and independent risk factor for cardiovascular disease. The deleterious effects of homocysteine included endothelial dysfunction, arterial intimal-medial thickening, wall stiffness and procoagulant activity. However, the precise mechanism responsible for homocysteine release in children with coronary artery disease is still unknown. The purpose of this study was to investigate serum homocysteine and tumor necrosis factor(TNF)-α... |
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- Measurement of the Common Carotid Artery by Ultrasound as a Predictor of Atherosclerosis in Obese Adolescents
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Ye Jin Kim, Yoon Hee Shim, Joung Hyun Yoo, Keun Lee, Young Mi Hong
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Clin Exp Pediatr. 2005;48(7):745-752. Published online July 15, 2005
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Purpose : Adolescent obesity is known to be associated with complications such as hypertension, coronary artery disease and insulin resistance. We measured the common carotid artery by ultrasound as a predictor of atherosclerosis, and investigated the relationship between carotid artery parameters and serum cytokines in obese adolescents.
Methods : Twenty-nine obese adolescents(16-17 years old, obesity index>130 percent) and twenty- seven... |
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- Serum Nitric Oxide and Tumor Necrosis Factor-α Levels in Patients with Kawasaki Disease
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Ji Hye Park, Jee Seon Shin, Young Mi Hong
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Clin Exp Pediatr. 2005;48(7):772-778. Published online July 15, 2005
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Purpose : Kawasaki disease(KD) is a systemic panvasculitis that causes coronary artery lesions. KD is accompanied by immunoregulatory abnormalities. Nitric oxide(NO) can induce relaxation of blood vessels by activating guanylate cyclase in smooth muscle cells and high levels of NO may result in coronary artery lesions. We investigated tumor necrosis factor(TNF)-α and NO production before and after intravenous immunoglobulin(IVIG) therapy... |
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- Pulmonary Function Test and Body Composition Analysis in Obese Children
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Jee Seon Shin, Ji Hye Park, Ji Young Kim, Su Jung Kim, Young Mi Hong
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Clin Exp Pediatr. 2005;48(6):588-593. Published online June 15, 2005
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Purpose : Obesity is associated with disturbances of ventilatory functions in adults. But few studies have evaluated the pulmonary complications of obesity in the pediatric population. The purpose of this study is to clarify the effects of obesity on pulmonary function and body composition in obese children.
Methods : Forty seven obese children whose ages ranged from nine to twelve... |
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- Chest X-ray Findings and Serum Tumor Necrosis Factor-α Levels in Patients with Kawasaki Disease
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Ji Young Kim, Jung Hyun Kwon, Kyung Hyo Kim, Jung Hyun Yu, Young Mi Hong
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Clin Exp Pediatr. 2005;48(5):534-538. Published online May 15, 2005
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Purpose : Kawasaki disease(KD) is a multisystemic inflammatory vasculitis of unknown etiology. Many complications other than cardiovascular involvement have been recognized in KD. However, there have been few reports published concerning involvement of the lungs in this disease. The purpose of this study was to examine the relationship between serum TNF-α, the degree of coronary artery dilatation and chest X-ray(CXR)... |
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- Gene Expression of Metalloproteinases, Tissue Inhibitors of Metalloproteinases and Cytokines in Adriamycin-induced Cardiomyopathy
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Young Mi Hong
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Clin Exp Pediatr. 2005;48(2):197-203. Published online February 15, 2005
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ity has been reported to occur in both clinical and experimental forms of dilated cardiomyopathy. There was no report about MMP in adriamycin(ADR)-induced cardiomyopathy. The purpose of this study was to investigate gene expression of MMP and tissue inhibitor of metalloproteinases(TIMP) in ADR-induced cardiomyopathy and clarify the relationship between MMP and cytokines.
Methods : Male Sprague-Dawley rats were divided into two... |
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- Serum Insulin, Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-3 Levels in Obese Adolescents
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Jung Hyun Kwon, Hyun Jin Kim, Young Mi Hong
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Clin Exp Pediatr. 2005;48(11):1172-1178. Published online November 15, 2005
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Purpose : Childhood Obesity is increasing throughout the world, and it is known to incur many diseases especially in later life such as diabetes and cardiovascular disorders. The purpose of this study was to investigate the association between obesity and insulin, insulin-like growth factor-I (IGF-I), insulin-like growth factor binding protein-3(IGFBP-3) and know if these factors are useful in predicting cardiovascular... |
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- A Study for Adiponectin in Obese Adolescents with Hypertension
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Jee Yoon Park, Su Jin Cho, Kyung Hyo Kim, Young Mi Hong, Keun Lee
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Clin Exp Pediatr. 2004;47(7):719-725. Published online July 15, 2004
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Purpose : The adipocyte has traditionally been known as a reservoir for energy, but currently there is growing evidence that the adipocyte plays an important role in the pathogenesis of energy metabolism and homeostasis. Adipocytokine released from the adipocyte has been known to play a role in diabetes mellitus, coronary artery disease and other diseases related with obesity. The purpose... |
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- Antithrombin III in the Diagnosis and Treatment of Disseminated Intravascular Coagulation in Premature Infants
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Su Jin Cho, Hye Ryung Choi, Young Mi Hong, Kyung Hee Kim, Keun Lee, Eun Ae Park
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Clin Exp Pediatr. 2004;47(7):740-745. Published online July 15, 2004
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Purpose : We evaluated the diagnostic implications and therapeutic efficacy of antithrombin III(AT III) in the disseminated intravascular coagulation(DIC) of premature infants.
Methods : Ninety-two premature infants diagnosed with DIC and treated with AT III from March, 2000 to May, 2003 were retrospectively reviewed. Clinical manifestations, complete blood counts, coagulation tests, and AT III levels were compared between the two groups... |
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- Methylenetetrahydrofolate Reductase(MTHFR) Gene Expression in Kawasaki Disease
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Hye Ryung Choi, Ae Ra Joo, Hae Soon Kim, Sejung Sohn, Young Mi Hong
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Clin Exp Pediatr. 2004;47(7):774-778. Published online July 15, 2004
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Purpose : Hyperhomocysteinemia is known as an independent risk factor for cardiovascular diseases such as atherosclesosis and myocardiac infarct. A common mutation in 5, 10-methylenetetrahydrofolate reductase(MTHFR) gene results in a valine for alanine substitution, which makes enzyme thermolabile and reduces enzymal activity. We examined the relation of MTHFR genetic mutation and Kawasaki disease.
Methods : We extracted DNA from the peripheral... |
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- Matrix Metalloproteinases, Tissue Inhibitors and Cytokines in Patients with Kawasaki Disease
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Ae Ra Cho, Young Mi Hong
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Clin Exp Pediatr. 2004;47(6):656-664. Published online June 15, 2004
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Purpose : Kawasaki disease(KD) is a multisystemic inflammatory vasculitis of unknown etiology, but immunological abnormalities have been documented and implicated in the pathogenesis of KD. Matrix metalloproteinases(MMPs) have proteolytic activity against connective tissue proteins, and increased activity of MMPs and a quantitative imbalance between MMP and tissue inhibitor of MMP (TIMP) can result in several pathologic conditions. MMP and TIMP... |
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- Aseptic Meningitis Secondary to High-Dose Intravenous
Immunoglobulin Therapy in Kawasaki Disease
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Ae Ra Cho, Jee Yoon Park, Kyung Hyo Kim, Young Mi Hong
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Clin Exp Pediatr. 2004;47(5):561-566. Published online May 15, 2004
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Purpose : Kawasaki disease is a multisystemic inflammatory vasculitis and associated with neurologic features such as aseptic meningitis. High-dose intravenous immunoglobulin(IVIG) is used to treat Kawasaki disease and generally considered to be safe, but rare cases of aseptic meningitis with unknown etiology have been reported. The aseptic meningitis associated with Kawasaki disease was compared with meningitis as the adverse reaction... |
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- Applicability of the "Questionnaire on Risk Factors Associated with Obesity in Adolescents" in School-Based Screening to Prevent Life Style Disease as a Result of Complicated Adolescent Obesity
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Yoon Hee Shim, Ji Young Kim, Soo Jeung Lee, Su Jin Cho, Whaan Kuck Yeong, Young Mi Hong
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Clin Exp Pediatr. 2004;47(12):1266-1272. Published online December 15, 2004
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Purpose: The prevalence of obesity and complications related to obesity among Korean adolescents were reviewed. To prevent obesity related complications in adolescents, the applicability of the "Questionnaire on risk factors associated with obesity in adolescents" as an assessment and management guideline was evaluated.
Methods: Weight, height, blood pressure and serum lipid and glucose level of 7,265 high school students in Seoul... |
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- Functional Antibody Responses to Seven Serotypes in Pneumococcal Polysaccharide Vaccine in Children
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Ji Hye Park, Hee Jung Kim, Young Mi Hong, Kyung Hyo Kim
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Clin Exp Pediatr. 2004;47(11):1173-1180. Published online November 15, 2004
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Purpose : Streptococcus pneumoniae is an important pathogen in children as well as in elderly people. The aim of this study was to assess the opsonization activity of pneumococal capsular antibody to seven serotypes in 23-valent pneumococcal polysaccharide vaccine before and after immunization in Korean children.
Methods : Nine children from 24 to 49 months of age were immunized with 23-valent... |
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- Correlation between Body Fat Percent Estimated by Bioelectrical
Impedance Analysis and Other Variable Methods
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Hye Won Yom, Su Jung Kim, Il Tae Whang, Young Mi Hong
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Clin Exp Pediatr. 2003;46(8):751-757. Published online August 15, 2003
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Purpose : Obesity is a significant health problem with medical and psychological consequences for children and adolescents. The purpose of this study was to assess the correlation between body fat percent using bioelectrical impedance(BI) and other variable methods.
Methods : We measured height, weight, body mass index(BMI) and body fat percent by skinfold thickness(ST) and BI in 1,035(496 male; 539 female)... |
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- Change of Cerebral Blood Flow during Tilt Tests in
Children with Vasovagal Syncope
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Su Jung Kim, Hye Won Yom, Young Mi Hong, Jung Hyen Yoo, Sook Hee Lee, Chong Hee Kim
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Clin Exp Pediatr. 2003;46(10):983-988. Published online October 15, 2003
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Purpose : Syncope appears to be common. However, the mechanism of syncope is not clear. Increased vagal activity and withdrawal of sympathetic stimulation cause hypotension, bradycardia and finally loss of consciousness. The purpose of this study was to evaluate changes of cerebral blood flow velocity, blood pressure, and heart rate during tilt test in children with vasovagal syncope.
Methods : Sixty... |
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- Changes of Serum Fatty Acid and Carnitine Levels after
Administration of L-carnitine in Rats
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Jae Won Lee, Young Mi Hong
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Clin Exp Pediatr. 2002;45(9):1075-1082. Published online September 15, 2002
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Purpose : Obesity is known to be associated with hypertension, dyslipidemia, and fatty liver and is thought to be associated with increased levels of free fatty acids. One of the strategies for decreasing free fatty acid levels is stimulation of hepatic lipid oxidation with L-carnitine. Carnitine is an essential cofactor for transport of long-chain fatty acid into mitochondria for oxidation.... |
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- Serum Fatty Acid and Carnitine Levels in
Obese Children with Fatty Livers
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Jin Bum Lee, Jae Won Lee, Young Mi Hong
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Clin Exp Pediatr. 2002;45(9):1083-1089. Published online September 15, 2002
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Purpose : The prevalence of obese children has recently increased. Obesity is known to be associated with complications such as hypertension, fatty liver, hyperlipidemia, and insulin resistance. L-carnitine is an essential cofactor for the transport of long chain fatty acids into mitochondria for β-oxidation. The purpose of this study is to measure serum free fatty acid and carnitine levels, and... |
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- Serogroup and Antimicrobial Resistance of
Streptococcus pneumoniae Isolated from Oropharynx in
Children Attending Day Care Center
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Kyung Hyo Kim, Jong Eun Lee, Il Tae Whang, Kyung Ha Ryu, Young Mi Hong, Gyoung Hee Kim, Keun Lee, Eun-Suk Kang, Ki-Sook Hong
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Clin Exp Pediatr. 2002;45(3):346-353. Published online March 15, 2002
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Purpose : Penicillin- and multidrug-resistant S. pneumoniae poses a serious threat to clinicians because the rate of resistance of S. pneumoniae to penicillin in Korea has surged up to the world's highest level. This study was performed to assess the carriage rate, serogroups and antimicrobial susceptibility of S. pneumoniae isolated from oropharynx in children.
Methods : From March to July 1998,... |
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- Body Composition by Bioelectrical Impedance Analysis in Obese Children
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Jong Eun Lee, Ki Won Par, Su Jin Cho, Il Tae Whang, Young Mi Hong
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Clin Exp Pediatr. 2001;44(9):992-1001. Published online September 15, 2001
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Purpose : Body composition by bioelectrical impedance analysis(BIA) is a very useful method of
analysing body composition in many diseases. BIA is a simple, rapid, non-invasive and reproducible
technique. There was no comparative analysis between obese and healthy children. A comparative
analysis between obese and healthy children is needed to assess the effect of excercise
and other interventions in the management of childhood obesity.... |
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- Risk Factors for Fatty Liver in Obese Children
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Ki Won Park, Jong Eun Lee, Kyung Ha Ryu, Kyung Hyo Kim, Young Mi Hong, Gyung Hee Kim, Keun Lee, Jeong Hyun Yoo
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Clin Exp Pediatr. 2001;44(6):669-676. Published online June 15, 2001
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Purpose : The incidence of obese patients has increased recently in Korea. Obesity is associated with hypertension, hyperlipidemia, insulin resistance, and fatty liver. Since recent investigators have revealed that not only fat accumulation but also fibrosis and nonspecific hepatitis can be found in the livers of obese children, fatty liver is currently considered as an important complication. The purpose of... |
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- Risk Factors for Cardiovascular Disease in Obese Children
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Su Jin Cho, Se Jin Park, Il Tae Hwang, Young Mi Hong
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Clin Exp Pediatr. 2001;44(5):493-500. Published online May 15, 2001
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Purpose : Obesity is known to be associated with complications such as hypertension, dyslipidemia, and insulin resistance. The importance of insulin resistance and hyperinsulinemia have been emphasized in obesity. Homocysteine is an emerging important risk factor for cardiovascular disease in adult, but there are less reports about homocysteine in children. Several risk factors such as blood pressure, lipid profiles, serum... |
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- Carriage and Antimicrobial Susceptibility of
Haemophilus influenzae Isolated from Oropharynges of Children
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Kyung Hyo Kim, Kyoung Ah Lim, Il Tae Whang, Young Mi Hong, Eun Sook Kang, Ki Sook Hong
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Clin Exp Pediatr. 2001;44(5):509-516. Published online May 15, 2001
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Purpose : Haemophilus influenzae, one of the normal flora of the upper respiratory tract, can cause such infections as otitis, sinusitis, pneumonia, and meningitis in children. The oropharyngeal flora has therefore mainly been analyzed as a reservoir for pathogens. This study was performed to reveal the colonization rate of H. influenzae in the upper respiratory tract, their biotypes, their antimicrobial... |
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- Relationship between Serum Leptin Levels and
Other Predictors in Obese Children
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Se Jin Park, Ki Won Park, Young Mi Hong
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Clin Exp Pediatr. 2001;44(10):1103-1111. Published online October 15, 2001
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Purpose : The product of the ob gene, leptin is an adipocyte specific hormone that might be involved in the regulation of food intake by the central neuroendocrine system. Recent studies reported that serum leptin concentrations were correlated with Body mass index(BMI) and other obesity measurements. The aims of this study were to evaluate leptin concentrations according to degree of... |
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- Oscillometric Blood Pressure Values of Infants and Children
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Hae In Suh, Young Mi Hong
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Clin Exp Pediatr. 2000;43(8):1029-1036. Published online August 15, 2000
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Purpose : Automated oscillometric blood pressure measurement is not used universally, but has a tendency to be used more frequently in pediatric areas. Reference values of blood pressure by this method were not reported on infants and children under 5 years of age in Korea. This study was performed to study normative blood pressure values by using oscillometric method, presenting... |
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- Nationwide Survey on Current Status of Formula Feeding in Infants
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Yon Ho Choe, Kyeong Rae Moon, Jeong Wan Seo, Jae Geon Sim, Kee Whan Yoo, Byeung Ju Jeong, Young Mi Hong
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Clin Exp Pediatr. 2000;43(7):878-888. Published online July 15, 2000
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Purpose : Although breast milk is considered the best source of nutrition for infants because of
its superiority over powdered milk, there are circumstances when breast milk is unavailable.
Committee on Nutrition of the Korean Pediatric Society conducted an investigation into the current
status of formula feeding in Korea.
Methods : This investigation was conducted using questionnaires produced by our committee and
distributed to mothers... |
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- Changes of Endothelin-1 after Pulmonary Venous Stenosis in Dog Model
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Young Mi Hong, Yong Soon Won, Seung Suk Kim
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Clin Exp Pediatr. 2000;43(6):769-778. Published online June 15, 2000
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Purpose : Endothelin-1(ET-1) is a potent vasoconstrictor peptide. It has potent contractile and proliferative effects on vascular smooth muscle cells. Congenital heart diseases are often accompanied by pulmonary hypertension, and the severity of pulmonary hypertension is important in the prognosis. The aim of this study was to elucidate changes of ET-1 after pulmonary venous stenosis in a dog model, and... |
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- Oscillometric Blood Pressure of Upper and Lower Extremities and Aortic Blood Flow Velocity in Neonates
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Sang Young Bae, Hae Soon Kim, Se Jung Sohn, Young Mi Hong
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Clin Exp Pediatr. 2000;43(4):484-488. Published online April 15, 2000
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Purpose : We studied the blood pressure difference between the upper and lower extremities in healthy newborn infants and the effect of isthmic narrowing of the aorta on making a possible difference.
Methods : The blood pressure was measured with an oscillometric blood pressure device from four extremities of 62 healthy infants aged 1-15 days. A Doppler echocardiography was performed for... |
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- The Changes of Apoptosis and Viability in Stem Cells after Thawing with Lapse of the Time
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Seun Joo Park, Sang Young Bae, Kyung Ha Ryu, Il Tae Whang, Kyung Hyo Kim, Young Mi Hong, Kyung Hee Kim, Keun Lee, Joo Young Seoh
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Clin Exp Pediatr. 2000;43(12):1576-1582. Published online December 15, 2000
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Purpose : Thawed stem cells should be infused as early as possible because delay of infusion leads to decrease of cell viability and formation of DNA clumping. The procedure of 10% Dimethyl sulfoxide(DMSO) removal and a long distance from the thawing location to the patient are the main causes of delay of infusion that results in the loss of cell... |
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- Serum Lipid Levels and Fatty Acid Metabolism in the Rat with Adriamycin Induced Cardiomyopathy
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Young Mi Hong, Hye Ran Yoon
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Clin Exp Pediatr. 2000;43(11):1480-1487. Published online November 15, 2000
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Purpose : Adriamycin induced cardiomyopathy is irreversible and may procede to clinical congestive heart failure. Recently, it has been suggested that adriamycin may exert cardiomyopathy due to inhibition of transport across mitochondrial membranes mediated by the carnitine palmitoyltransferase system(CPT I). The effect of adriamycin on fatty acid metabolism according to cumulative dose was not clarified. The purpose of this study... |
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- Effects of Ductal Closure on Flow Velocities of Peripheral Pulmonary Arteries in Normal Term Infants
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Hae-Soon Kim, Se Jeong Sohn, Young Mi Hong
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Clin Exp Pediatr. 2000;43(10):1318-1322. Published online October 15, 2000
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Purpose : This study was performed to evaluate whether a relationship may exist between transient peripheral pulmonary stenosis and the closure of the ductus arteriosus in term infants.
Methods : A total of 69 healthy full-term infants had pulmonary artery and ductal color Doppler flow velocity assessment performed at of 10 hours age(group I), 1-2 days of age(group II), and... |
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- Effect of Low-Dose Aspirin Therapy on Platelet Aggregation in Kawasaki Disease
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Ju Yeon Yeo, Heon Eui Le, Young Mi Hong, Ki Sook Hong, Wha Soon Chung
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Clin Exp Pediatr. 1999;42(4):510-518. Published online April 15, 1999
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Purpose : Aspirin(acetylsalicylic acid) has been used to treat unstable angina and acute myocardial infarction in adults and Kawasaki disease in children. The antithrombotic effect of aspirin was attributed to its ability to inhibit platelet aggregation by inhibiting platelet cyclooxygenase, which leads to decreased thromboxane synthesis. The purpose of this study was to evaluate the effect on the platelet aggregation... |
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- Estimating Fetal Cardiac Output by Doppler Echocardiography
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Young Mi Hong
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Clin Exp Pediatr. 1999;42(2):203-210. Published online February 15, 1999
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Purpose : Doppler echocardiography has been used to identify fetal cardiac anatomy and hemodynamics. It can estimate flow velocity, volume, and cardiac output. The purposes of this study were to estimate right and left ventricular stroke volume and cardiac output in fetus, and to see if there were any changes of right and left ventricular parameter with fetal growth.
Methods :... |
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- Diagnostic Utility of D-dimer Test in Disseminated Intravascular Coagulation with Sepsis
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Jung Eun Kim, Young Mi Hong, Gyung Hee Kim
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Clin Exp Pediatr. 1999;42(2):257-263. Published online February 15, 1999
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Purpose : Disseminated intravascular coagulation(DIC) is a confusing disorder from both a diagnostic and therapeutic standpoint.
In order to investigate the effectiveness of D-dimer test in disseminated intravascular coagulation associated with sepsis, D-dimer level and other laboratory tests were performed.
Methods : Fifty patients with disseminated intravascular coagulation associated with sepsis, who were admitted to the department of pediatrics, were evaluated by... |
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- Effects of Respiration on Right and Left Ventricular Diastolic Function in Normal Children
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Hae-Soon Kim, Young Mi Hong
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Clin Exp Pediatr. 1999;42(10):1412-1418. Published online October 15, 1999
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Purpose : To evaluate the effects of respiration on diastolic filling pattern in normal children by Doppler echocardiography.
Materials and Methods : Doppler echocardiograms of the tricuspid and mitral valves were recorded with electrocardiogram and respirations in 46 normal children aged 3months to 14years(7.6¡¾3.5year). We measured the following variables: heart rate, the peak E and A velocities, the area under the... |
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- A Nationwide Clinical Study of Acute Respiratory Distress Syndrome in Children
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Soo Jung Choi, Do Suck Jeong, Jae Won Oh, Ha Baik Lee, Im Ju Kang, Kwang Woo Kim, Kyu Earn Kim, Ki Bok Kim, Young Ho Rah, Kang Seo Park, Byong Kwan Son, Ki Young Lee, Sang Il Lee, Ji Tai Choung, Young Mi Hong
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Clin Exp Pediatr. 1999;42(1):23-31. Published online January 15, 1999
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Purpose : Acute respiratory distress syndrome(ARDS) is the final course of acute lung injury. It results from various etiological origins and pathophysiologic mechanisms, and has a mortality rate of approximately 60-70%. Although the confirmative incidence of ARDS in children is yet unknown, the increasing incidence of ARDS has been reported in Korea. In the present study, we report ARDS diagnosed... |
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- Microdeletion of Chromosome 7 in Williams Syndrome and Supravalvular Aortic Stenosis
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Ho Sung Kim, Yoon Sung Kang, Kyung Hyo Kim, Young Mi Hong, Yong Soo Yun, Kwang Ho Lee
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Clin Exp Pediatr. 1999;42(1):47-59. Published online January 15, 1999
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Purpose : Williams syndrome is characterized by supravalvular aortic stenosis, mental retardation and peculiar facial appearance. Its genetic etiology is considered to be a hemizygotic deletion in Chromosome 7q11.23, which includes the elastin gene. We examined the hemizygotic deletion of Chromosome 7q11.23 in 12 Korean Williams syndrome patients and 8 patients with isolated supravalvular aortic stenosis and performed deletion mapping... |
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- The Relationship between IL-1β, TNFα, IL-6 and Factors Associated with Febrile Reactions to Transfused Blood
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Hae Shin Kyung, Kyung Ha Ryu, Kyung Hyo Kim, Young Mi Hong, Kyung Hi Kim, Keun Lee
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Clin Exp Pediatr. 1999;42(1):108-114. Published online January 15, 1999
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Purpose : Aggressive chemotherapy and bone marrow transplantation have a large demand for platelet concentrate and packed RBC transfusion. Febrile nonhemolytic transfusion reactions are an immunologically mediated reaction involving plasma in the recipient and the white blood cells in the donor. This study was performed to understand the role of cytokines and factors associated with febrile nonhemolytic transfusion reaction to... |
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- The Role of Apoptosis in Adriamycin Induced Cardiotoxicity and Preventive Effect of L-carnitine in Rat
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Young Mi Hong, Seung Sook Kim
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Clin Exp Pediatr. 1998;41(6):760-768. Published online June 15, 1998
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Purpose : Adriamycin is very important in cancer chemotherapy. Unfortunately, the drug shows
cumulative dose dependent cardiotoxicity. The precise mechanism of this remains unclear. It has
been shown that adriamycin induces programmed cell death or apoptosis in many tissues. But the
role of apoptosis in adriamycin induced cardiotoxicity is uncertain.
Methods : Sprague-Dawley rats were divided into four groups of ten animals each. All... |
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- Normal Predicted Values of Pulmonary Function Test in Healthy Korean Children
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Seung Yeon Nam, Kyung Hyo Kim, Young Mi Hong, Gyoung Hee Kim
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Clin Exp Pediatr. 1998;41(3):338-345. Published online March 15, 1998
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Purpose : We performed a pulmonary function test with simple, computerized spirometry composed
of pneumotachometry and evaluated the predicted normal values of air flow rates and lung volumes
in healthy Korean children. We calculated each of the simple and complex linear and logarithmic
regression equations setting the predicted values.
Methods : Four hundred and fifty-two healthy children were enrolled from December, 1994 to
August, 1995.... |
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- Left Ventricular Mass Estimated by Three Methods of Echocardiography in Normal Children
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Yae Jean Kim, Soo Ja Hwang, Dong Hee Shin, Young Mi Hong
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Clin Exp Pediatr. 1998;41(2):192-199. Published online February 15, 1998
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Purpose : Left ventricular hypertrophy is an important diagnostic and prognostic finding in children with various cardiovascular diseases. Echocardiographic determination of the left ventricular mass is the most accurate method for assessing left ventricular hypertrophy non-invasively. The purposes of this study are 1) to establish a reproducible, validated method for determining left ventricular mass in children by echocardiography, 2) to... |
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- Cardiovascular Doppler Flow Waveforms in Human Fetuses
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Young Mi Hong
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Clin Exp Pediatr. 1998;41(12):1639-1649. Published online December 15, 1998
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Purpose : Doppler echocardiography has been used to identify fetal cardiac anatomy and hemodynamics. It can estimate flow velocity, volume, and cardiac output. The purpose of this study was to look at cardiovascular waveforms in fetus and to see if there were any changes in Doppler parameter with fetal growth.
Methods : Blood velocity studies were performed across the mitral, tricuspid,... |
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- Diagnostic Sensitivity in Predicting Hyperlipidemia by Bioelectrical Impedance Analysis in Obese Children
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Ji Ah Jung, Hyun Mi Kim,, Young Mi Hong, Gyoung Hee Kim
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Clin Exp Pediatr. 1998;41(11):1583-1589. Published online November 15, 1998
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Purpose : Childhood obesity is currently on the rise. The complications of childhood obesity are depression, adult obesity, hypertension, diabetes, hyperlipidemia, coronary artery disease and fatty liver. Therefore, accurate diagnosis of obesity is important. The purpose of this study was to assess diagnostic sensitivity to predict hypelipidemia by bioelectrical impedance analysis(BI) in obese children.
Methods : One hundred fifteen healthy... |
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- Urinary Interleukin-1β Levels in Children with Urinary Tract Infection
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Kyung Hyo Kim, Young Mi Hong, Gyoung Hee Kim
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Clin Exp Pediatr. 1997;40(7):981-990. Published online July 15, 1997
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Purpose : IL-1β and TNF-α are important mediators of the inflammatory response in serious
bacterial infections. The mucosal and systemic IL-1β and TNF-α responses to urinary tract
infection are analyzed in children with acute urinary tract infection.
Methods : We studied the levels of these two cytokines in the urine and sera of 21 children at
diagnosis and after treatment with sandwich ELISA method.
Results... |
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- Dermatophagoides Pteronyssinus Specific IgG-subclass Antibodies in Allergic Children
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Soo Ja Hwang, Kyung Hyo Kim, Young Mi Hong
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Clin Exp Pediatr. 1997;40(5):701-707. Published online May 15, 1997
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Purpose : Although immunoglobulin E play a major role in immediate hypersensitivity reactions, some reaginic activity is associated with IgG. Part of the reaginic activity is associated with IgG1, IgG4.
In contrast with this reaginic activity of IgG4, allergen-specific IgG4 antibody is allergen neutralizing antibody and contribute to the benificial effect of immunotherapy. The role of specific IgG antibody in allergic... |
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- Comparison of Left and Right Ventricular Volume and Cardiac Output by MRI and Echocardiography
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Young Mi Hong
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Clin Exp Pediatr. 1996;39(7):962-969. Published online July 15, 1996
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Purpose : Ventricular volume and cardiac output are very important to evaluate cardiac fuction.
Cine MRI has been found to a feasible technique in evaluating cardiac anatomy and
cardiovascular function in a variety of cardiac disease. Measurement of left ventricular volume by
cine MRI was closely correlated with the result by echocardiography or cine angiography.
The purpose of this study is to compare the... |
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- Predictor of Fatty Liver in Obese Children
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Hyunmi Kim, Young Mi Hong, Gyoung-Hee Kim, Jung Hyun Yu
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Clin Exp Pediatr. 1996;39(6):803-810. Published online June 15, 1996
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Purpose : The childhood obesity is currently increasing. The childhood obesity is
difficult to treat and the response of treatment is transitory because it is caused by the hyperplasia of fatcells. The complications of obesity are hyperlipidemia, hypertension, diabetes, artherosclerotic coronary arterial disease and fatty liver. Therefore the early diagnosis and prevention of obesity from childhood is very important. This study... |
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- Case Report
- A Case of Cystic Pancreatoblastoma Associated with Congenital Hemihypertrophy
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Hyun Joo Lee, Kyuong Ha Yoo, Young Mi Hong, Kyung hee Kim, Kum Ja Choi, Joung Hyun Yoo, Sung Sook Kim
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Clin Exp Pediatr. 1996;39(6):861-865. Published online June 15, 1996
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We experenced a case of cystic pancreatoblastoma associated with congenital hemihypertrophy in a 4months old male. The mass was located on the anterior side of pancreatic head without any connection to the pancreas. After exision of cystic pancreatoblastoma, chemotherapy(FAM regimen) was performed 15 times due to capsular tumor invasion. Until this time there was no drug side effect and metastasis.... |
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- Original Article
- Serum Secretory CD4 and CD8 Levelsin Kawasaki Disease
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Kyung Hyo Kim, Young Mi Hong, Gyoung Hee Kim
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Clin Exp Pediatr. 1996;39(4):543-551. Published online April 15, 1996
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Purpose : Kawasaki disease (KD) is an acute febrile illness of infancy and early childhood characterized by diffuse vasculitis. Although the disease is generally self-limited, up to 25% of untreated patients with KD may develop coronary artery abnormalities. The acute phase of KD is characterized by marked activation of the immune system leading to increased cytokine production by immune effector... |
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- Study of Epstein Barr Virus Antibodies in Patients with Kawasaki Disease
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Dong Hee Shin, Kyung Hyo Kim, Young Mi Hong, Gyung Hee Kim
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Clin Exp Pediatr. 1996;39(11):1603-1610. Published online November 15, 1996
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Purpose : The etiology of the Kawasaki disease remains unclear, many strong clinical and
epidemiologic characteristics suggest an infectious etiology. However, conventional bacterial and
viral cultures and extensive serologic studies have not revealed a consistent causative agent. Thus
we studied the Epstein Barr virus(EBV), one of the most important pathogens, to access the
association between the EBV and Kawasaki disease.
Methods : Seventy-two patients with... |
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- Evaluation of Abnormal Coronary Artery Flow in Anomalous Coronary Artery Connections by Pulsed and Color Doppler Echocardiography
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Young Mi Hong
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Clin Exp Pediatr. 1996;39(1):78-87. Published online January 15, 1996
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Purpose : Anomalous connection of coronary artery can result in damage of myocardial
perfusion, myocardial infarction, or congestive heart failure. Echocardiography has been used to demonstrate coronary artery anomalies such as coronary artery fistula, anomalous origin of the left coronary artery from the pulmonary artery, and aneurysm of the coronary arteries in Kawasaki disease. Definitive diagnosis relies on cardiac catheterization The... |
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- CorreJation between High Blood Pressure and Lipid Profile in School Children
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Young Mi Hong, Yun Ju Kang, Sung Jae Suh
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Clin Exp Pediatr. 1995;38(12):1645-1652. Published online December 15, 1995
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Purpose : Adult essential hypertension begins in early childhood. Blood pressure patterns in children differ from those in adults, and the design of hypertension programs need to modified for young people.
Hypertension in children is associated with several factors, but correlation with lipid profiles is not unknown. The purpose of this study is to analyze the affecting factors in child hypertension... |
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- 3 Cases of Kawasaki Disease Associated Thrombocytopenia
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Hye Soon Kim, Young Mi Hong, Seung Joo Lee
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Clin Exp Pediatr. 1995;38(12):1686-1690. Published online December 15, 1995
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Kawasaki disease may be associatde with a variety of hematologic abnormalities, the most characteristic being thrombocytosis. Thrombocytopenia, in contrast, appears to occur rarely in children with this disease. Hera et al observed the 2% manifested thrombocytopenia early in their illness. To our knowledge, early thrombocytopenia has not been reported in other populations, We report the case of a children with... |
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- Pulmonary Venous Flow Pattern by Doppler Echocardiography before and after Closure of Ductus Arteriousus in Newborns
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Young Mi Hong
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Clin Exp Pediatr. 1994;37(9):1213-1219. Published online September 15, 1994
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Color Doppler echocardiography was performed to evaluate pulmonary venous flow pattern at 1st~2nd day of birth in 84 fullterm newborns (36: patent ductus arteriosus, 48: closed ductus arteriosus). Aortic and pulmonic diameter, velocity and integral were estimated.
The purpose of this study ascertained that patent ductus arteriosus changed the pulmonary vein velocity and flow integral. The results were... |
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- Case Report
- A Case of Congenital T Cell Lymphoblastic Lymphoma
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Eun Sun Yoo, Young Mi Hong, Kyung Hee Kim, Hae Soo Gyu, Eun Chul Chung
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Clin Exp Pediatr. 1994;37(9):1296-1304. Published online September 15, 1994
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T cell lymphoblastic lymphoma is characterized by immature lymphoid cells that are indistinguishable from the lymphoblasts and prolymphocytes of acute lymphoblastic leukemia. Several characteristic clinical features of lymphoblastic lymphoma, with include a high male-to-female ratio, a relatively high incidence in older children and young adults, the frequent presence of mediastinal involvement at the time of diagnosis. Also, this disease is... |
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- Original Article
- Evaluation of Pulmonary Venous, Mitral and Aortic Flow Pattern by Doppler Echocardiography in Neonates
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Hye Soon Kim, Young Mi Hong, Gyoung Hee Kim
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Clin Exp Pediatr. 1994;37(5):596-605. Published online May 15, 1994
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Pulmonary vein velocities have recently been estimated in conjunction with mitral flow velocities to increase our understanding of ventricular filling. The advent of transesophageal echocardiography with pulsed doppler imaging capability has provided a method by which both the mitral valve and pulmonary vein velocities can be easily recorded because of the posterior approach providing unimpeded interrogation of cardiac structures.
The purpose... |
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- Comparative Study on the Allergy Skin Test and RAST in Allergic Patients
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Il Tae Whang, Young Mi Hong, Gyoung Hee Kim
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Clin Exp Pediatr. 1994;37(12):1693-1700. Published online December 15, 1994
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The allegic skin test and RAST are used commonly to demonstrate the presence of skin sensitizing IgE antibody in the diagnosis of allergic disease.
To evaluate the agreement rate and correlation between results of skin test and RAST (radioallergosorbent test) in allergic subject, 83 allergic childgood with positive skin test (bronchial asthma: 26, allergic rhinitis: 27, atopic dermatitis and urticaria: 6... |
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- Airway Resistance after Exercise Loading Test in Asthmatic Children
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Ji Eun Lee, Young Mi Hong, Kyung Hee Kim
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Clin Exp Pediatr. 1994;37(10):1333-1339. Published online October 15, 1994
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Exercise induced asthma(EIA) is defined as acute, reversible, usually self-immiting airway obstruction which develop after strenous exercise in patients with asthma. EIA is a bigger problem in children than adults due to more active and smaller airways which obstruct more easily when bronchospasm develops. The exercise elicited amny change in pulmonary function of asthmatic children. These change could be measured... |
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- Dermatophagoides Farinae Specific IgG-Subclass Antibody in Allergic Children
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Young Mi Hong, Kyung Hyo Kim, Eun Ae Park, Gyoung Hee Kim
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Clin Exp Pediatr. 1993;36(10):1651-1358. Published online October 15, 1993
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For determining the distribution of specific IgE and IgG-subclass antibodies and their role in allergic disorders, we measured the serum levels of specific IgG-subclass and IgE antibodies to Dermatophagoides farinae(Df) on 60 atopic children, aged between 8 to 12. All of them had positive skin test to Df, and was grouped into three: children with asthma only (group 1), with... |
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- Case Report
- Acquired Persistent Cytomegalovirus Infection : An Association with Common Variable Immunodeficiency
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Min Hyea Kim, Young Mi Hong, Sung Joo Lee, Je Geun Chi, Dong Soo Kim
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Clin Exp Pediatr. 1992;35(9):1272-1279. Published online September 15, 1992
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Acquired persistent cytomegalovirus infection was diagnosed by anti CMV antibody and lymph node biopsy and persisted in a 3-year-old boy with recurrent episode of high fever, lymphadenopathy hepatosplenomegaly and pneumonia.
Initial immunologic abnormalities including low serum IgG, high IgM decreased T4 and T4/T8 ratio finally progressed to immunologic paralysis which was compatible to common variable immunodeficiency.
This is the first case which... |
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- Adult Respiratory Distress Syndrome in Infancy
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Hoo Jae Hann, Young Mi Hong, Seung Joo Lee
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Clin Exp Pediatr. 1992;35(2):245-251. Published online February 15, 1992
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Adult Respiratory distress Syndrome (ARDS) is a clinical entity characterized by respiratory distress and diffuse pulmonary infiltrates due to increased permeability after various kinds of insult to alveolar-capillary membrane.
We experienced a case of ARDS in a 3-1/2 month old girl after Pseudomonas pneumonia, cardiac arrest and generalized convulsion.
This is the report on her clincal and autopsy findings with brief review... |
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- Original Article
- Blood Flow Velocity in the Ascending Aorta and Main Pulmonary Artery of Children by Doppler Echocardiography
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Young Mi Hong
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Clin Exp Pediatr. 1992;35(10):1343-1354. Published online October 15, 1992
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The purpose of this study is to establish normal values for Doppler aortic and pulmonary artery flow velocity measurements, adjusted for age and the other parameters, which might be used for evaluating patients with suspected abnormalities of left and right sided hemodynamics.
Blood flow velocity measurements were made in the ascending aorta and proximal main pulmonary artery of 117 pediatric normal... |
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- The effect of ultrasonic nebulized salbutamol in the first attacked wheezy infants.
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Soo Young Kweon, Young Mi Hong, Gyung Hee Kim, Seung Joo Lee, Keun Lee
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Clin Exp Pediatr. 1991;34(11):1505-1511. Published online November 30, 1991
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Wheezing is one of the most common symptom in the first 2 year of life.
Although the effect of bronchodilator in wheezy infants was still debating, various form of
bronchodilator has been tried untill now.
This study was done to estimate the value of ultrasonic nebulized salbutamol as a bronchodilator
test and maintenance therapy compared to epinephrine and aminophylline in 44 wheezy infants below
24... |
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- The Change of Anti-HBs Titer after Hepatitis B Vaccination in Newborn.
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Ji Hye Kang, Young Mi Hong, Seung Joo Lee
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Clin Exp Pediatr. 1990;33(5):598-605. Published online May 31, 1990
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Hepatitis B vaccination is an accepted preventive measure for all newborn as well as the risk
group. However, there is some uncertainty about the persistence of anti-HBs and the timing of
booster vaccination.
We studied anti-HBs titer, positive rate and minimum protective rate in relation to time interval
after the third vaccination in 102 infants bom to HBsAg negative mother (Group I) and 52... |
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- A Case of Transient Myeloproliferative Disorder in Down's Syndrome.
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Ji Hye Kang, Young Mi Hong, Kyung Hee Kim, Seung Joo Lee, Ki Sook Hong, Ok Kyung Kim, Je Geun Chi
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Clin Exp Pediatr. 1990;33(2):252-258. Published online February 28, 1990
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Transient myeloproliferative disorder has been reported in infant with Down's syndrome during
neonatal period.
This is clinically and hematologically indistinguishable from congenital acute leukemia. In contrast
to congenital leukemia, complete clinical and hematological recovery occurs within weeks to months
of diagnosis without antileukemic treatment.
A neonate presented with jaundice, hepatosplenomegaly and mongoloid face was diagnosed as
Transient myeloproliferative disorder.
We report this case with a review of... |
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- The Diameter of Coronary Arteries in Infants and Children Without Heart Disease.
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Young Mi Hong
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Clin Exp Pediatr. 1990;33(10):1353-1361. Published online October 31, 1990
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Two dimensional echocardiographic examinations of the proximal left and right coronary artery
were performed in 140 infants and children without heart disease. Eighty boys and 60 girls were
studied whose ages ranged from newborn to 15 years old. The diameter of the proximal left cornonary
artery was 0.8 mm in newborn and 1.9 mm in teenagers.
The diameter of the proximal right coronary artery... |
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- A Study on Anemia of Acute Infectious Disease in Children.
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Hae Won Lee, Young Mi Hong, Seung Joo Lee, Keun Lee
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Clin Exp Pediatr. 1990;33(1):75-80. Published online January 31, 1990
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The anemia of acute infectious disease has come to attention recently, since iron deficiency anemia
has decreased. We screened for anemia in children admitted to Ewha Womans University Hospital
due to acute infectious disease between January 1, 1986 and July 31, 1988, and studied the incidence
and characteristics of anemia in acute infectious diseases.
The result were as follows:
1) The incidence of anemia in acute... |
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- Clinical Strudy of chlamydial Pneumonia in Early Infants.
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Mi Kyung Kim, Young Mi Hong, Seung Joo Lee, Keun Lee
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Clin Exp Pediatr. 1990;33(1):51-58. Published online January 31, 1990
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We studied Chlamydiazyme test in 55 infants below 6 months of age with lower respiratory tract
infection, admitted to the Pediatric ward of Ewha Womans University Hospital, between October 1,
1987 and February 28, 1989. The results were as follows.
1. The overall incidence of Chlamydial pneumonia was 14,5% (8/55). All of them were below 2
months of age, so the incidence in infants below... |
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- ABO Gene Frequency in ABO Hemolytic Disease of Newborn.
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Young Mi Hong, Keun Lee
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Clin Exp Pediatr. 1988;31(9):1105-1113. Published online September 30, 1988
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ABO hemolytic disease in newborn due to ABO incompatibility between mother and infant is one of
common cause of neonatal hyperbilirubinemia and early detection has been emphasized due to its
possible neurologic sequelae. Many studies reported prevalence difference of ABO hemolytic disease
in various races, which could be ascribed to different frequency of ABO genes in races.
From Feb. 1986 to May 1987 full... |
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- Case Report
- A Case of Toxic Epidermal Necrolysis.
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Gye Ja Lee, Yong Aee Chun, Young Mi Hong, Young Min Ahn, Se Hoon Park
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Clin Exp Pediatr. 1986;29(3):342-347. Published online March 31, 1986
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Toxic epidermal necrolysis appears to be a hypersensitivity phenomenon triggered by many factors: drugs, infections, vaccination, radiotherapy and malignancies. Widespread epidermal necrolysis rapidly follows blister formation at epidermal-dermal junction. The case fatality rate is approximately 25%. The disease consists of a prodrome of malaise, lethargy, and fever followed by erythema and massive bullae formation. This paper presented a case... |
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- A Case of Morgagni Hernia Confirmed by Diagnostic Pneumoperitoneum.
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Young Mi Hong, Hae Seung Kim, Joong Gon Kim, Keun Lee, Seung Yeul Yoo
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Clin Exp Pediatr. 1982;25(12):1266-1269. Published online December 31, 1982
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A case of Morgagni hernia in 3day old newborn is reported with literature review. The
patient developed tachypnea and respiratory difficulty on 3rd day of life and the diagnosis
was made by diagnostic pneumoperitoneum.
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- A Case of Potter Syndrome.
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Young Mi Hong, Hae Seung Kim, Jung Gon Kim, Keun Lee
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Clin Exp Pediatr. 1982;25(11):1181-1184. Published online November 30, 1982
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In 1946 Potter described a series of 20 cases in infants in whom bilateral absence of the
kidneys was associated with, hypoplasia of the lung and characteristic face. The main facial
features she described were increased space between the eyes, a prominent fold which arises
at inner canthus and sweeps downward and laterally below the eyes, unusual flattening of the
nose, excessive recession of... |
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